The SAM Lab is interested in the role of sleep and circadian regulation in metabolic and cardiovascular homeostasis. Specifically, we study how sleep and circadian disruption impair whole body and tissue-specific function, and whether improving the timing of behaviors such as sleep, exercise and eating can improve health and reduce disease risk.
CURRENT RESEARCH PROJECTS
SELECT PUBLICATIONS
For a comprehensive publication list, please click here.
Erickson ML, Dobias D, Keleher MR, Dabelea D, Bergman BC, Broussard JL, Boyle KE. In Vitro Circadian Clock Gene Expression Assessments in Mesenchymal Stem Cells from Human Infants: A Pilot Study. Nutrients. 2023 Dec 23;16(1):52. doi: 10.3390/nu16010052. PMID: 38201882.
Broussard JL, Knud-Hansen BC, Grady S, Knauer OA, Ronda JM, Aeschbach D, Czeisler CA, Wright KP Jr. Influence of circadian phase and extended wakefulness on glucose levels during forced desynchrony. Sleep Health. 2023 Nov 22;. doi: 10.1016/j.sleh.2023.10.010. PMID: 37996284
Singh P, Beyl RA, Stephens JM, Noland RC, Richard AJ, Boudreau A, Hebert RC, Ravussin E, Broussard JL, St-Onge MP, Marlatt KL. Effect of sleep restriction on insulin sensitivity and energy metabolism in postmenopausal women: A randomized crossover trial. Obesity (Silver Spring). 2023 May;31(5):1204-1215. doi: 10.1002/oby.23739.
Chaput JP, McHill AW, Cox RC, Broussard JL, Dutil C, da Costa BGG, Sampasa-Kanyinga H, Wright KP Jr. The role of insufficient sleep and circadian misalignment in obesity. Nat Rev Endocrinol. 2023 Feb;19(2):82-97. doi: 10.1038/s41574-022-00747-7. PMID: 36280789.
Broussard JL and Klein S. Insufficient sleep and obesity risk: cause and consequence. Obesity. in press.
Petersen MC, Gallop MR, Flores Ramos S, Zarrinpar A, Broussard JL, Chondronikola M, Chaix A, Klein S. Complex Physiology and Clinical Implications of Time-restricted Eating. Physiological Reviews. in press.
Blankenship JM, Vetter C, Broussard JL. Impairments in Glycemic Control During Eastbound Transatlantic Travel in Healthy Adults. SLEEPAdvances. 2022. doi.org/10.1093/
Ritchie HK, & Broussard JL. Insufficient sleep is responsible for increased risk of metabolic disease in shift workers. Journal of Physiology. 2022 Feb 24;. doi: 10.1113/JP282189. PMID: 35218007.
Hanlon EV, Van Cauter E; Tasali E, Broussard JL. 2021. Principles and Practice of Sleep Medicine. 7th edition. Chapter 27: Endocrine Physiology in Relation to Sleep and Sleep Disturbances.
Amato KR, Arrieta MC, Azad MB, Bailey MT, Broussard JL, Bruggeling CE, Claud EC, Costello EK, Davenport ER, Dutilh BE, Swain Ewald HA, Ewald P, Hanlon EC, Julion W, Keshavarzian A, Maurice CF, Miller GE, Preidis GA, Segurel L, Singer B, Subramanian S, Zhao L, Kuzawa CW. The human gut microbiome and health inequities. Proc Natl Acad Sci U S A. Jun 22;118(25). 2021.
Broussard JL, Perreault L, Macias E. Newsom SA, Harrison K, Bui HH, Milligan P, Roth KD, Nemkov T, D’Alessandro A, Brozinick JT, Bergman BC. Sex differences in insulin sensitivity are related to muscle tissue acylcarnitine but not subcellular lipid distribution. Obesity, Mar;29(3):550-561. 2021
Thomas EA, Zaman A, Cornier M, Catenacci VA, Tussey EJ, Grau L, Arbet J, Broussard JL, Rynders CA. Later Meal and Sleep Timing Predicts Higher Percent Body Fat. Nutrients, 13(1), 73. 2021.
Rynders CA, Morton SJ, Bessesen DH, Wright KP Jr., Broussard JL. Circadian rhythm of substrate oxidation and hormonal regulators of energy balance. Obesity. 22 May 2020. doi:10.1002/oby.22816.
Brouwer A, Bediako IA, Paszkiewicz RL, Kolka CM, Bergman RN, Broussard JL. Impact of sleep deprivation and high-fat feeding on insulin sensitivity and beta cell function in dogs. Diabetologia, 63(4), 875-884. DOI 10.1007/s00125-019-05084-5. View in: PubMed
Broussard JL, Reynolds AC, Depner CM, Ferguson SA, Dawson D, Wright KP. Jr. Circadian Rhythms versus Daily Patterns in Human Physiology and Behavior; pp 279-295. In V. Kumar Ed. Biological Timekeeping: Clocks, Rhythms and Behaviour. 2017.
Broussard JL, Van Cauter E. Disturbances of sleep and circadian rhythms: novel risk factors for obesity. Curr Opin Endocrinol Diabetes Obes. 2016 Oct; 23(5):353-9. View in: PubMed
Broussard JL, Devkota S. The changing microbial landscape of Western society: Diet, dwellings and discordance. Mol Metab. 2016 Sep; 5(9):737-42. View in: PubMed
Broussard JL, Kilkus JM, Delebecque F, Abraham V, Day A, Whitmore H, Tasali E. Elevated ghrelin predicts food intake during experimental sleep restriction. Obesity. 2016; 24(1):132-8.
Broussard JL, Kolka C, Castro AVB, Asare IB, Paszkiewicz RL, Szczepaniak EW, Szczepaniak LS, Knutson KL, Kim SP, Bergman RN. Elevated nocturnal NEFA are an early signal for hyperinsulinemic compensation during diet-induced insulin resistance. Diabetologia. 2015; 58(11):2663-70.
Broussard JL, Chapotot F, Abraham V, Day A, Delebecque F, Whitmore H, Tasali E. Sleep restriction increases free fatty acids in healthy men. Diabetologia. 2015; 58(4):791-798.
Broussard JL, Ehrmann D, Van Cauter E, Tasali E, Brady M. Experimental Reduction of Sleep Duration Is Associated with Impaired Insulin Signaling in the Adipocyte. Ann Intern Med. 2012 Oct 16;157(8):549-57.